Graduate Thesis Or Dissertation
 

Public health impact assessment : a science-based methodology for comparing biological agents

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/12579x25n

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  • Humans have long suffered the effects of disease causing biological agents. Today bioterrorism appears to be on the rise while at the same time global and ecological changes have resulted in the emergence of new diseases. Potential repercussions of an epidemic pose immense challenges requiring a methodical approach to align priorities and resources. Past assessments evaluating the potential impact of an introduction of various biological agents have often produced disparate results, primarily due to underlying differences in their comparison methodologies and data inputs. Divergent outcomes of these studies have resulted in very broad biopreparedness strategies without a consensus on how to target limited resources on just those agents that could have the greatest public health impact. Further hampering biopreparedness is a paucity of data not often recognized due to reliance on subject matter experts and qualitative processes. In consideration of these challenges the present study evaluated thirty three bacterial and viral agents using the full range of available data in the scientific literature. Quantitative metrics were combined to rank the potential impact posed by an agent, relative to others considered. Resultant rankings were obtained for low, most likely and high potential public health impacts for both untreated and treated mortality endpoints. Through the incorporation of the full range of available data, results of the current assessment made strides to unify conflicting outcomes obtained in past assessments.
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