Graduate Thesis Or Dissertation
 

Dose response of zebrafish exposed to gamma radiation

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  • Space radiation biology is an emerging field of research with a focus on improving the health and safety of astronauts in low-Earth orbit (LEO) and deep-space missions. Eye health is especially important to astronaut functionality. Recent studies have found an increased risk of cataract formation in astronauts with higher lens doses (> 8 mSv) of space radiation relative to astronauts with lower lens doses (< 8 mSv). In order to better understand cataract formation from ionizing radiation zebrafish embryos were exposed to various levels of γ-rays. Zebrafish embryos were exposed at 24 hour post fertilization (hpf) and examined shortly after irradiation and 120 hpf. At 120 hpf, mortality increased to over 80% at doses ≥ 30 Gy. Morbidity increased to over 75% at ≥ 15 Gy. New zebrafish embryos were then exposed to various levels of ionizing radiation at 4 days post fertilization (dpf) and showed no discernable differences in morbidity and mortality one day after irradiation. The next phase of research will expose adult zebrafish to Iodine- 128 to examine the differences in damage from γ-ray exposure and β-particle exposure.
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