Dose response of zebrafish exposed to gamma radiation Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/2514np951

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Space radiation biology is an emerging field of research with a focus on improving the health and safety of astronauts in low-Earth orbit (LEO) and deep-space missions. Eye health is especially important to astronaut functionality. Recent studies have found an increased risk of cataract formation in astronauts with higher lens doses (> 8 mSv) of space radiation relative to astronauts with lower lens doses (< 8 mSv). In order to better understand cataract formation from ionizing radiation zebrafish embryos were exposed to various levels of γ-rays. Zebrafish embryos were exposed at 24 hour post fertilization (hpf) and examined shortly after irradiation and 120 hpf. At 120 hpf, mortality increased to over 80% at doses ≥ 30 Gy. Morbidity increased to over 75% at ≥ 15 Gy. New zebrafish embryos were then exposed to various levels of ionizing radiation at 4 days post fertilization (dpf) and showed no discernable differences in morbidity and mortality one day after irradiation. The next phase of research will expose adult zebrafish to Iodine- 128 to examine the differences in damage from γ-ray exposure and β-particle exposure.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Keyword
Subject
Rights Statement
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Laura Wilson(laura.wilson@oregonstate.edu) on 2014-01-23T22:12:08Z (GMT) No. of bitstreams: 1 HaskinsHillaryK2014pdf.pdf: 1456987 bytes, checksum: 2f7f7b6c67465dc1c2ac36c5684ddb6d (MD5)
  • description.provenance : Approved for entry into archive by Julie Kurtz(julie.kurtz@oregonstate.edu) on 2014-01-23T18:20:19Z (GMT) No. of bitstreams: 1 HaskinsHillaryK2014pdf.pdf: 1456987 bytes, checksum: 2f7f7b6c67465dc1c2ac36c5684ddb6d (MD5)
  • description.provenance : Made available in DSpace on 2014-01-23T22:12:08Z (GMT). No. of bitstreams: 1 HaskinsHillaryK2014pdf.pdf: 1456987 bytes, checksum: 2f7f7b6c67465dc1c2ac36c5684ddb6d (MD5) Previous issue date: 2013-12-16
  • description.provenance : Submitted by Hillary Haskins (haskinsh@onid.orst.edu) on 2014-01-22T22:01:13Z No. of bitstreams: 1 HaskinsHillaryK2014pdf.pdf: 1456987 bytes, checksum: 2f7f7b6c67465dc1c2ac36c5684ddb6d (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items