Evaluation of serum amyloid A and haptoglobin as prognostic indicators for horses in a referral population Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/37720h12g

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  • Acute phase protein (APP) measurement can be used to characterize and rapidly detect inflammation. Serum amyloid A (SAA) and haptoglobin (HP) may be useful for diagnostic and prognostic purposes in horses presenting for colic and other inflammatory diseases. The objective of this thesis was to evaluate the use of SAA and HP in horses presenting for colic and inflammatory diseases for prognostic application of case outcome. We examined case outcomes such as development of complications, survival outcome, duration and cost of hospitalization, and requirement for surgical intervention in horses presenting for colic. Specific laboratory values measured included total white blood cell count, neutrophil count, fibrinogen, SAA, HP, which were compared in control horses and horses admitted for colic and inflammatory diseases. Clinicopathologic values were compared in medical and surgical colic cases to test the ability of APPs to predict indication for surgical intervention. Survival outcome, development of complications, and hospitalization cost and duration were analyzed in both in horses presenting for colic and inflammatory diseases. In horses presenting for colic, SAA was significantly higher in the surgical group compared to both the control and medical colic groups. Haptoglobin concentration was not significantly different between all groups. Horses with elevated SAA were more likely to require surgical intervention than those medically managed. Euthanasia due to poor prognosis or the development of serious complications were more likely to occur in horses presenting for colic with an elevated SAA. In horses presenting for inflammatory diseases, admission SAA and HP concentrations were not significantly associated with survival or the development of complications. Increased HP concentration on admission was associated with longer duration of hospitalization in hoses with inflammatory diseases. Horses with an increasing SAA between 24-72 hours compared to admission SAA were more likely to be euthanized or develop complications. The findings of this study show that SAA and HP measurement could be a potential useful diagnostic and prognostic tool in horses presenting for colic and inflammatory diseases.
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