Perinatal and postweaning effects of the interaction between maternal ethanol ingestion and low dietary zinc in the rat Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/44558h445

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  • This research was designed to study the perinatal and postweaning effects of the interaction between ethanol and low dietary zinc during gestation and lactation in the rat. Pregnant rats were fed liquid diets containing either 2 or 10 μg zinc/ml with or without 30% of kcal from ethanol throughout gestation and lactation. The liquid diet formulation was nutritionally adequate to insure offspring growth and survival during lactation. At weaning, dams and five of eight offspring from each litter were killed by exsanguination under sodium pentobarbital anesthesia. The remaining offspring were orally inoculated with Streptococcus mutans and fed a caries-promoting diet for six weeks. The low zinc diet produced a moderate zinc deficiency in dams as evidenced by a decrease in tissue zinc content, serum alkaline phosphatase activity, and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner but the magnitude was smaller. The maintenance of a lower than normal maternal tissue zinc and decreased maternal urinary excretion of zinc suggested a maternal attempt to support the growth and development of offspring despite zinc deficiency. Physiological consequences of ethanol-antagonized zinc status were evidenced by depressed activity of maternal and offspring serum alkaline phosphatase, increased maternal urinary excretion of hydroxyproline, decreased offspring molar enamel and dentin zinc content, increased dental caries score, and decreased cross-linking structure of mandibular second molar enamel. The liquid diet developed in the present study was nutritionally adequate and allowed for the investigation of a single nutrient deficiency, zinc, in ethanol fed rats during gestation and lactation without confounding effects of general malnutrition. Although the direction of interaction was predominately an effect of ethanol on zinc rather than the effect of zinc on ethanol, this study clearly indicates that zinc deficiency is an important consequence of maternal ethanol ingestion.
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  • description.provenance : Made available in DSpace on 2012-01-26T18:21:56Z (GMT). No. of bitstreams: 1 YEHLEE1984.pdf: 1108496 bytes, checksum: e136bb8b7fb104c776ecd073aadce13f (MD5) Previous issue date: 1984-02-22
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-01-26T18:21:56Z (GMT) No. of bitstreams: 1 YEHLEE1984.pdf: 1108496 bytes, checksum: e136bb8b7fb104c776ecd073aadce13f (MD5)
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