Development of self-registration features for the assembly of a microchannel hemodialyser Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/44558h95n

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • More than 1.2 million people worldwide require regular hemodialysis therapy to treat end stage renal failure. In the United States alone, there are 300,000 patients and the National Kidney Foundation predicts that this number will double in the next 10 years. Currently most dialysis patients receive treatment at a dialysis center and need three 4-5 hour treatments each week. While these treatments are useful, more frequent and longer duration dialysis better simulates natural kidney function. Consequently, at-home hemodialysis is expected to provide patients a better quality of life. Current hemodialysis systems are too expensive to support at-home hemodialysis. Cost drivers include the capital costs of the hemodialysis equipment and the raw material costs of expensive hemodialysis membranes. Microchannel hemodialysers have smaller form factors requiring significantly less membrane while enabling reductions in the size and cost of capital equipment. Microchannel devices are typically made by microchannel lamination methods involving the patterning, registration and bonding of thin laminae. Findings in this paper show that membrane utilization is highly dependent on registration accuracy with membrane utilization often dropping below 25%. Efforts here focus on the development of a self-registration method for assembling microchannel hemodialysers capable of supporting registration accuracies below 25 μm over a 50 mm polycarbonate lamina. Using these methods, registration accuracies below 13 μm were measured over a 50 mm scale. A mass transfer test article was produced with measured average one dimensional misregistration below 19 μm with a demonstrated membrane utilization of 44.9% when considering both microchannel and header regions. Mass transfer results suggest that the device performed with a mass transfer area of 90.59 mm². A design is proposed describing membrane utilization of over 79%.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Laura Wilson(laura.wilson@oregonstate.edu) on 2012-09-18T19:56:12Z (GMT) No. of bitstreams: 1 PorterSpencerD2012.pdf: 1822406 bytes, checksum: 98918a28b4a595ba973c3b06aa2dac47 (MD5)
  • description.provenance : Submitted by Spencer Porter (portersp@onid.orst.edu) on 2012-09-10T22:01:21Z No. of bitstreams: 1 PorterSpencerD2012.pdf: 1512332 bytes, checksum: 13ceb75379d6865d66986cb01cda2f6b (MD5)
  • description.provenance : Approved for entry into archive by Julie Kurtz(julie.kurtz@oregonstate.edu) on 2012-09-12T15:39:50Z (GMT) No. of bitstreams: 1 PorterSpencerD2012.pdf: 1822406 bytes, checksum: 98918a28b4a595ba973c3b06aa2dac47 (MD5)
  • description.provenance : Submitted by Spencer Porter (portersp@onid.orst.edu) on 2012-09-11T21:57:34Z No. of bitstreams: 1 PorterSpencerD2012.pdf: 1822406 bytes, checksum: 98918a28b4a595ba973c3b06aa2dac47 (MD5)
  • description.provenance : Made available in DSpace on 2012-09-18T19:56:12Z (GMT). No. of bitstreams: 1 PorterSpencerD2012.pdf: 1822406 bytes, checksum: 98918a28b4a595ba973c3b06aa2dac47 (MD5) Previous issue date: 2012-09-06
  • description.provenance : Rejected by Julie Kurtz(julie.kurtz@oregonstate.edu), reason: Rejecting to revise Table of Contents. Once revised open the item that was rejected. Replace the attached file with the revised file and resubmit. Thanks, Julie on 2012-09-11T18:20:23Z (GMT)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items