Some toxicological aspects of Ruelene, an organophosphate, used systemically to control ectoparasites Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/4j03d2357

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  • Ruelene was orally administered to three female sheep at a dosage rate of 121.5 mg /kg. The cholinesterase (ChE) activity levels of blood plasma, red blood cells (RBC), and mosquitoes (Aedes aegypti) which had fed on the sheep were tested at various times before and after dosage. Maximum depression of the sheep blood ChE activity occurred at the fourth hour after dosage, while the major depression of mosquito ChE activity occurred at the fifth hour. Mosquito death occurred first at an average of 35% mosquito ChE activity inhibition and 100% mortality was observed at an average of 56% inhibition. Mortality in Dermacentor andersoni was also tested. Groups of ticks which had fed on the treated sheep for seven hours or more after dosage sustained mortalities of 80-100%.
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