Label free biosensing with carbon nanotube transistors Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/5138jj57v

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  • As electronics reach nanometer size scales, new avenues of integrating biology and electronics become available. For example, nanoscale field-effect transistors have been integrated with single neurons to detect neural activity. Researchers have also used nanoscale materials to build electronic ears and noses. Another exciting development is the use of nanoscale biosensors for the point-of-care detection of disease biomarkers. This thesis addresses many issues that are relevant for electrical sensing applications in biological environments. As an experimental platform we have used carbon nanotube field-effect transistors for the detection of biological proteins. Using this experimental platform we have probed many of properties that control sensor function, such as surface potentials, the response of field effect transistors to absorbed material, and the mass transport of proteins. Field effect transistor biosensors are a topic of active research, and were first demonstrated in 1962. Despite decades of research, the mass transport of proteins onto a sensor surface has not been quantified experimentally, and theoretical modeling has not been reconciled with some notable experiments. Protein transport is an important issue because signals from low analyte concentrations can take hours to develop. Guided by mass transport modeling we modified our sensors to demonstrate a 2.5 fold improvement in sensor response time. It is easy to imagine a 25 fold improvement in sensor response time using more advanced existing fabrication techniques. This improvement would allow for the detection of low concentrations of analyte on the order of minutes instead of hours, and will open the door point-of-care biosensors.
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  • description.provenance : Rejected by Julie Kurtz(julie.kurtz@oregonstate.edu), reason: Rejecting to remove page numbers on pretext pages. Thanks, Julie on 2011-06-10T16:49:53Z (GMT)
  • description.provenance : Approved for entry into archive by Julie Kurtz(julie.kurtz@oregonstate.edu) on 2011-06-10T17:27:54Z (GMT) No. of bitstreams: 3 license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5) LeydenMatthewR2011.pdf: 3796487 bytes, checksum: efb15a284a5d79ac7d6e093022bd128a (MD5)
  • description.provenance : Submitted by Matthew Leyden (leydenm@onid.orst.edu) on 2011-06-09T22:09:15Z No. of bitstreams: 4 LeydenMatthewR2011Pretext.pdf: 352351 bytes, checksum: 9d2bf464137ca8221737d474967a391f (MD5) LeydenMatthewR2011Main.pdf: 3543309 bytes, checksum: 2721de166f5bef6ed6b48ed417aa4165 (MD5) license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5)
  • description.provenance : Submitted by Matthew Leyden (leydenm@onid.orst.edu) on 2011-06-10T16:52:30Z No. of bitstreams: 3 license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5) LeydenMatthewR2011.pdf: 3796487 bytes, checksum: efb15a284a5d79ac7d6e093022bd128a (MD5)
  • description.provenance : Submitted by Matthew Leyden (leydenm@onid.orst.edu) on 2011-06-10T00:33:14Z No. of bitstreams: 3 LeydenMatthewR2011.pdf: 3626619 bytes, checksum: 682d9d036f42642349cf5aee267aed5a (MD5) license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5)
  • description.provenance : Made available in DSpace on 2011-06-10T18:01:28Z (GMT). No. of bitstreams: 3 license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5) LeydenMatthewR2011.pdf: 3796487 bytes, checksum: efb15a284a5d79ac7d6e093022bd128a (MD5)
  • description.provenance : Rejected by Julie Kurtz(julie.kurtz@oregonstate.edu), reason: Rejecting because there are two PDFs and their should be only one. Once merged into one document, open the item that was rejected. Replace the attched files with the revised file and resubmit. Thanks, Julie on 2011-06-09T22:40:57Z (GMT)
  • description.provenance : Approved for entry into archive by Laura Wilson(laura.wilson@oregonstate.edu) on 2011-06-10T18:01:28Z (GMT) No. of bitstreams: 3 license_rdf: 22588 bytes, checksum: ea670c3d41c679fe14ddd27ddad3face (MD5) license_text: 21030 bytes, checksum: afb2f9aa0e51fd9c78a12390c7ef29a0 (MD5) LeydenMatthewR2011.pdf: 3796487 bytes, checksum: efb15a284a5d79ac7d6e093022bd128a (MD5)

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