Inhibition of exercise-induced oxidative stress, inflammation and muscle damage by prior supplementation with the antioxidant vitamins E and C Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/5712m896m

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  • To determine if 6 weeks prior supplementation with vitamins E and C could alleviate exercise-induced DNA damage, prevent lipid peroxidation and inflammation, slow the rate of vitamin E utilization and/or attenuate muscle damage, 22 subjects (11 females: 11 males) were studied during a 50 km (32 mile) ultramarathon. Subjects were randomly assigned to treatment groups: placebos (PL) or antioxidants (AO, vitamin E (300 mg RRR-a-tocopheryl acetate) and 1000 mg vitamin C (500 mg twice per day)). Subjects consumed deuterium-labeled vitamin E (75 mg d₆-RRR-a-tocopheryl acetate) 48 h prior to race start. Multiple blood samples were obtained for measurements of DNA damage, unlabeled and labeled a-tocopherols and their metabolites, ascorbic acid, markers of lipid peroxidation (plasma F2-isoprostanes (F₂-lsoPs)), inflammation and muscle damage. Maximal voluntary contraction (MVC) of the knee flexors/extensors was assessed. Plasma x-tocopherol and ascorbic acid increased in the AO but not the PL group following 6 weeks of supplementation. All subjects completed the race; average run time 7.1 ± 0.1 h. The run induced non-persistent DNA damage; % DNA damage increased at mid-race (p<0.02), but returned to baseline by 2 h post-race. One day post-
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