Graduate Thesis Or Dissertation
 

Some aspects of an hemophilus infection in the laboratory rat

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  • There is need for more knowledge of the naturally acquired diseases of the laboratory rat. Respiratory diseases occurring in the species were reviewed with special reference to an acute respiratory disease affecting certain rats in the Oregon State University closed Wistar rat colony which has also involved human infections. The genus hemophilus was discussed, particularly Hemophilus influenzae, Hemophilus para-influenzae and Hemophilus influenzae murium. Necropsy and bacteriological examinations were made of rats from the O.S.U. colony affected with the acute respiratory syndrome noted above. The lesions observed are described. An organism morphologically and culturally similar to H. para-influenzae was isolated. The organism was inoculated intranasally into susceptible experimental animals. These rats were necropsied at three, five, ten, and 14 days. The histopathological picture was observed and described. The organism was recovered from the test animals. Lesions observed in the animals affected by the disease at the present time were compared to those seen in rats dying during the initial epizootic four years ago. In 1964-65 the rat colony was infected with chronic murine viral pneumonia. The rats were less able to resist the infection with the causal agent and succumbed. The breeding colony for the present rats has been raised for several generations in barrier cages and the colony is now apparently free of chronic murine viral pneumonia. The rats which now become infected on removal from the barrier cages do not develop the advanced lesions previously observed. The principal lesion now is seen to be a purulent rhinitis with a mild conjunctivitis. Human involvement in the initiation of the primary epizootic was suspected and there has been human infection apparently contracted from handling the infected rats reported subsequently. During the present studies a similar human infection occurred and an organism considered to be the same as the isolate from the rats was recovered. The identity of the isolate is discussed. In the previous studies the isolate was considered to be Hemophilus influenzae murium. Evidence is presented in the present study to indicate that it is Hemophilus pares-influenzae.
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