Graduate Thesis Or Dissertation
 

A Micro Scale Magnetic Particle Imaging System

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/6w924h92q

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  • Magnetic particle imaging (MPI) is a biomedical imaging technique which detects the presence of magnetic nanoparticles which have been introduced into the specimen prior to imaging. MPI has shown promise for real-time imaging with spatial resolution comparable to magnetic resonance imaging (MRI). MPI research has focused predominantly on the development of systems suitable for imaging small animals, and with image capture times on the order of seconds to support real-time imaging. To accommodate these goals, a spatial resolution of 1 mm is typical. However, MPI has also shown promise for imaging features as small as 100 μm which would be suitable for the observation of cells. Conducting microscopy utilizing a magnetic imaging device allows for deeper imaging than possible with light-based microscopy. Cellular behavior is understood to be different within larger cell structures than in isolated tissue samples. Enabling cellular resolution imaging in larger tissue samples or in vivo would allow for a more accurate understanding of cellular function in the body. This work presents the design, measurement, and modeling for a novel MPI scanner intended to have a spatial resolution of 100 μm thus suitable for cellular resolution microscopy in larger tissue samples or in vivo.
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  • I would like to acknowledge National Science Foundation Award No. 1310657 for helping make this work possible.
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