Graduate Thesis Or Dissertation
 

Aminophylline dosing in congestive heart failure

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  • A study was designed to examine the pharmacokinetics of theophylline in a well defined group of congestive heart failure (CHF) patients, without liver disease, and to evaluate the validity of the dosage guidelines recommended by the FDA. A total of five CHF patients and seven non-CHF patients were entered and studied. There was no significant difference between the mean theophylline clearance of the CHF group, 37.4 ml/kg/hr, and the non-CHF group, 36.3 ml/kg/hr (p > 0.05). The number of patients in the therapeutic range, 9/11, was compared to the number predicted to be in the therapeutic range following FDA guidelines, 0/11. This difference was highly significant (p = 0.002). The current FDA dosage guidelines may produce inadequate, subtherapeutic serum levels in patients requiring theophylline. Further study of dosages designed to achieve therapeutic serum concentrations is suggested.
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  • File scanned at 300 ppi (Monochrome) using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
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