The CMOS two-stage Operational Transconductance Amplifier (OTA) has been a key enabler for mixed-signal IC design for nearly four decades . This research focuses on a modified two-stage CMOS OTA that features load-pole cancellation (LPC); i.e., the resulting architecture is essentially a two-stage CMOS OTA with no load capacitance. The load-pole cancellation is achieved by adding an addi- tional stage to the conventional Miller-compensated two-stage OTA. The compen- sation scheme is inherently Process-Voltage-Temperature (PVT) insensitive and a single-ended implementation achieves an 8x power improvement in a TSMC 180nm process. Design optimizations to maximize power savings for the LPC OTA are explored using a gm/id-based approach. Fully-differential class-AB architectures of the OTA are designed in a 180nm process that mitigate the slew-rate limitations seen in class-A versions of the LPC OTA. The OTA has been implemented in an amplifier, switched-capacitor filter and a low-dropout regulator.