Influence of riboflavin doses on the urinary excretion of riboflavin and 4-pyridoxic acid in young men Public Deposited

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  • The influence of riboflavin doses on the urinary excretion of riboflavin and 4-pyridoxic acid was investigated in 6 young men. Doses of crystalline riboflavin and/or pyridoxine were administered on days 10 to 25 using a 6 X 6 Latin square design. The 6 crystalline vitamin doses given were: 0.3 mg and 0.6 mg pyridoxine; 1.2 mg and 2.4 mg riboflavin: 0.3 mg pyridoxine with 1.2 mg riboflavin and 0.6 mg pyridoxine with 2.4 mg riboflavin. On day 28 each subject received 0.06 mg riboflavin. On days 30 to 45, 6 food doses of known riboflavin content were administered to the subjects using a 6 X 6 Latin square design. All crystalline vitamin and food doses were separated by two days. All subjects consumed a constant diet during the experimental period. Twenty-four-hour urine collections were made throughout the study. Urinary riboflavin excretion increased in response to the 1.2 mg and 2.4 mg riboflavin doses but not after the 0.06 mg dose. Urinary riboflavin excretion increased after the milk dose only. Bioavailability of riboflavin in non-fat dry milk, which was estimated by reference to the riboflavin dose response curve, was 61 ± 35 (mean ± S.D.) percent. In 4 of the 6 subjects urinary 4-pyridoxic acid excretion was suppressed when riboflavin was administered with pyridoxine. Additionally, in four subjects the 2.4 mg riboflavin dose depressed urinary 4-pyridoxic acid excretion to a level below that seen with the 1.2 mg riboflavin dose. These results provide additional supporting evidence for a riboflavin/vitamin B-6 interaction.
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