Employing capillary electrophoresis as a separation method for pharmaceutical analysis Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/8s45qc19k

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  • Capillary electrophoresis as a technique has many applications in a broad range of fields including forensics, environmental analysis, and biological analysis and as a separation method for samples such as oligonucleotides, peptides, proteins, and pharmaceuticals. The research conducted herein is for the antibiotic pharmaceutical ciprofloxacin HCl and three impurities. Sample stacking was used to overcome the poor limits of detection generally associated with CE, which successfully improved the limits of detection when compared to results from a previous feasibility study. This thesis encompasses three stages: method development, limit of detection determination, and proof of successful method development by analysis of tablets of ciprofloxacin. The method developed is reproducible, yields high resolution, and provides intense signals with respect to the detection generally achievable with capillary electrophoresis. The limits of detection of the impurities were determined to be below 0.05% (by concentration) of that of the active ingredient, and a brief tablet analysis showed that formulated tablets could be analyzed with this method.
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