Preformulation studies for oral dosage forms of lactobacilli Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/8s45qc35z

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Lactobacilli have been used in the dairy and pharmaceutical industries because of their nutritious and/or therapeutic effects. Lactobacillus acidophilus and Lactobacillus bulqaricus were isolated from a commercially available product and studied for their growth and colony characteristics as described in Chapter I and Chapter II. Survival of these lactobacilli in simulated gastric and intestinal fluids was also studied to obtain information useful in evaluating previously reported literature data and in developing oral formulations of lactobacilli. Preformulation and formulation research included study of non-coated as well as enteric coated capsules and tablets. Calcium alginate gel beads were also formulated and found to not prevent diffusion of hydrogen ions. Lactobacillus preparations were evaluated for survival during exposure to gastric fluid, intestinal fluid, freeze-drying, and storage.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome, 24-bit Color) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Submitted by Katy Davis (kdscannerosu@gmail.com) on 2013-07-08T15:09:25Z No. of bitstreams: 1 LiouGraceY1985.pdf: 1460948 bytes, checksum: 3f4051032717434bc2195ad63a7b7b33 (MD5)
  • description.provenance : Made available in DSpace on 2013-07-19T20:44:02Z (GMT). No. of bitstreams: 1 LiouGraceY1985.pdf: 1460948 bytes, checksum: 3f4051032717434bc2195ad63a7b7b33 (MD5) Previous issue date: 1984-07-11
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-07-19T20:44:02Z (GMT) No. of bitstreams: 1 LiouGraceY1985.pdf: 1460948 bytes, checksum: 3f4051032717434bc2195ad63a7b7b33 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-07-08T22:11:55Z (GMT) No. of bitstreams: 1 LiouGraceY1985.pdf: 1460948 bytes, checksum: 3f4051032717434bc2195ad63a7b7b33 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items