Graduate Thesis Or Dissertation
 

The effects of mirex on biliary excretion of bile salts and phenolphthalein glucuronide in male rats

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  • Rats exposed to one or two doses of 60 mg mirex/kg by gavage exhibited hypertrophied livers and various degrees of hepatobiliary dysfunction. Although single dosed animals demonstrated elevated whole liver bile flow after 96 hours, the single dose was insufficient to significantly inhibit whole liver hepatobiliary performance as measured by the biliary excretion of exogenously supplied phenolphthalein glucuronide (PG) and endogenous bile salts. Two doses of mirex on consecutive days lead to significantly greater liver hypertrophy than a single dose, reduced excretion of bile salts and PG in the first 15 minutes following infusion on both a per gram and whole liver basis, and depressed bile salt excretion on a gram liver basis. Maximal disruption of hepatobiliary excretory performance was apparent 96 hours after the second mirex dose.
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Déclaration de droits
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