Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/9306t2393

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  • A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the relative effect of five different phytochemicals commonly used as dietary supplements using the high-fat fed C57BL/6J mouse as a model for the obesigenic Western diet (HF). In each study, diets were formulated to include levels of phytochemicals that could be reasonably achieved with a typical dietary supplement use. Animals were fed experimental diets ad libitum and body weight and food intake was recorded weekly. Glucose tolerance tests were conducted and urinary albumin-to-creatinine ratio was determined using metabolic cages. At the end of each of the studies, animals were sacrificed, serum collected, and kidney tissue saved for RNA isolation and gene expression analysis. The results of the three studies varied slightly but certain trends were observed in all three studies. Gene expression measurements were made via RT-PCR in liver and kidney to evaluate the expression of genes, related to lipid metabolism and transport, renal podocyte function, and gene transcription factors. Gene regulation changes were consistent with improved hepatic lipid metabolism and renal podocyte function with phytochemical consumption. These studies support the conclusion that the consumption of some phytochemicals in fruits and green tea has a positive effect on metabolic health of the liver and kidney.
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