Peritoneal clearance of vitamin B-6 and evaluation of vitamin B-6 and vitamin A status in children undergoing continuous ambulatory peritoneal dialysis (CAPD) Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/9k41zh530

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  • The objectives of this study were to determine the peritoneal clearance of vitamin B-6 and to evaluate the vitamin B-6 and vitamin A status of children with chronic renal failure undergoing continuous ambulatory peritoneal dialysis (CAPD). Eight children aged 2 to 18 years (mean 12) were included in the study. Mean time on CAPD was 27.2 months. Vitamin supplements were discontinued 3 weeks prior to the study. Dietary intake of vitamin B-6, vitamin A and protein were estimated from a 3 day dietary record. Plasma was analyzed for total vitamin B-6 (total B-6), pyridoxal 5'-phosphate (PLP) and retinol. Dialysate and urine were analyzed for total B-6, PLP and protein. Mean total B-6 was 197, 34.7, and 257.7 nM for plasma, dialysate and urine, respectively. Mean plasma PLP was 25.5 nM while no PLP was detected in dialysate. Mean plasma retinol was 617 ug/dl. No retinol was detected in the dialysate. B-6 supplements are important in these children while vitamin A supplements should not be given and dietary vitamin A should be restricted.
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