Graduate Thesis Or Dissertation

 

Glycogen utilization in newborn rats subjected to cold stress Público Deposited

Contenido Descargable

Descargar PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/bv73c3231

Descriptions

Attribute NameValues
Creator
Abstract
  • Newborn rats exhibit a torporous response to cold stress at 2°C from which they revive after several hours exposure even though respiratory, cardiovascular, and muscular movements have ceased. At less severe temperatures (20 to 25°C) the rats respond with a non-torporous decrease in metabolic and physiologic activity and a lowering of body temperature to that of the environment. This experiment was an attempt to determine if anaerobic glycolysis contributed to the energy required during the period of anoxic torpor at 2°C, as well as the role of glycogen at 22°C. Control animals were kept at 32°C (nest temperature). After newborn rats had been exposed to one of the three experimental temperatures (2, 22, or 32°C) for a specified time interval up to ten hours, they were killed by quick-freezing. Samples of liver and muscle tissue were analyzed for glycogen concentration or for lactic acid. Survival time at 2 to 6°C was indicated in a separate group of animals by signs of life during rewarming: It was found that glycogen was depleted to a greater extent during cold exposure than at nest temperature. This indicates that the effects of cold inhibited those factors maintaining glycogen more than those factors utilizing it. The degree of lactic acid increase at 2°C indicated anaerobic glycolysis, while more complete oxidation of glycolytic intermediates was suggested at 22°C. Older animals were found to have a significantly higher liver glycogen concentration than younger ones, yet they succumbed to cold more readily than did the younger rats. This indicates that maturation affected resistance to cold more than did glycogen concentration.
Resource Type
Fecha Disponible
Fecha de Emisión
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Declaración de derechos
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces

Relaciones

Parents:

This work has no parents.

En Collection:

Elementos