Graduate Thesis Or Dissertation
 

Multi-Modal Biosensing with Diatom Photonic Crystal Biosilica

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  • The need to detect trace amounts of target molecules is great, particularly when it comes to biosensing. With the early detection of a disease, the odds of the successful treatment of an individual increases significantly. To enhance the capability of biomolecular detection, we have created an optical biosensor capable of the enhancement of multi-modal optical signals. Our substrate employs diatoms, a type of algae, with unique optical properties to achieve multi-modal enhancement. Diatom shells, called frustules, are made of biosilica with quasi-periodic pores. These frustules exhibit a very large surface area which allows for a large area of interaction for analytes. Additionally, the porous structure of the frustule acts as a photonic crystal capable of enhancing optical signals. Here we demonstrate the multi-modal enhancement capabilities of our biosensor through the detection of biological analytes using colorimetric shifts, surface enhanced Raman scattering and fluorescence biosensing.
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file details SquireKennethJ2017.pdf 2017-11-08 Pubblico Scaricare