Graduate Thesis Or Dissertation
 

The effect of phototherapy on dopamine in dextrose 5% water stability in vitro

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  • The stability of dopamine in dextrose 5% water subjected phototherapy was assessed. Solutions of dopamine (1000 mcg/ml) were prepared and triplicate samples were subjected to one of three light (normal, dark, phototherapy) and two flow (2ml/hr. and no flow) conditions at ambient room temperature. Photo-irradiance was maintained between 5.1 and 6.6 watts/cm² throughout the experiment. Samples were assayed at intervals from 0 to 36 hours by high performance liquid chromatography (HPLC). There was no statistically significant decomposition of dopamine solutions exposed to phototherapy as compared to control samples over time. Dopamine in dextrose 5% water exposed to phototherapy is stable for 36 hours. The results of this study indicate that the need for additional protection of dopamine from blue light irradiance emitted by phototherapy is not needed to maintain stability during administration to neonates.
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