The disposition of four therapeutically important antimicrobial agents in llamas Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/dj52w808n

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The disposition of four therapeutically important antimicrobial agents was studied in llamas following intravenous bolus administration. Six llamas were each given ampicillin, tobramycin, trimethoprim and enrofloxacin at a dose of 12 mg/kg, 1 mg/kg, 3 mg/kg and 5 mg/kg of body weight with a wash out period of 3 days between each treatment. Plasma concentrations of these antimicrobial agents over 12 hours following IV bolus dosing were determined by reverse phase HPLC. Dispositions of these four antimicrobial agents were described by two compartment open model with elimination from the central compartment, and also by non-compartmental methods. From compartmental analysis, the elimination rate constant, half-life, and apparent volume of distribution in the central compartment were determined. Statistical moment theory was used to determine non-compartmental pharmacokinetic parameters of mean residence time, clearance, and volume of distribution at steady-state. Based on the disposition parameters determined, a dose and dosing interval for each of the four antimicrobial agents was suggested for llamas. Steady state peak and trough plasma levels were also predicted for the drugs in this study for llamas.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using Capture Perfect 3.0.82 on a Canon DR-9080C in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-12-28T18:01:28Z (GMT) No. of bitstreams: 1 MurdandeSharadB1994.pdf: 2118452 bytes, checksum: 1bc5ad6c4a8d3f9dbe358854a70340ea (MD5)
  • description.provenance : Submitted by Sergio Trujillo (jstscanner@gmail.com) on 2012-12-19T00:33:49Z No. of bitstreams: 1 MurdandeSharadB1994.pdf: 2118452 bytes, checksum: 1bc5ad6c4a8d3f9dbe358854a70340ea (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-12-19T20:07:36Z (GMT) No. of bitstreams: 1 MurdandeSharadB1994.pdf: 2118452 bytes, checksum: 1bc5ad6c4a8d3f9dbe358854a70340ea (MD5)
  • description.provenance : Made available in DSpace on 2012-12-28T18:01:30Z (GMT). No. of bitstreams: 1 MurdandeSharadB1994.pdf: 2118452 bytes, checksum: 1bc5ad6c4a8d3f9dbe358854a70340ea (MD5) Previous issue date: 1994-01-05

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items