Intercalation on hydrocarbons in polynucleotides Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/dr26z1638

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The binding of eleven polycyclic, aromatic hydrocarbons to the acid form of poly A has been investigated. The hydrocarbons were chosen to test a size criterion. Model building showed that some hydrocarbons could intercalate in the helix and be well protected from contact with the aqueous solvent. Experimentally it was found that those hydrocarbons which were small enough to be protected were bound to poly A. Hydrocarbons which were too large to be so protected did not bind. A size criterion for the binding of hydrocarbons to poly A therefore exists. The flow dichroism of four poly A-hydrocarbon complexes was measured. The flow dichroism measurements were consistent with the intercalation model. The dissociation energy of several hydrocarbons is found to occur in an order that is different from that given by the size criterion. There was no correlation between the binding of individual hydrocarbons to poly A and the energy of dissocation of individual hydrocarbons from the crystalline state. The size criterion for poly A, together with a previously examined size criterion for DNA, and the flow dichroism data serve as unequivocal evidence that hydrocarbons intercalate in polynucleotides.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-01-31T17:37:17Z (GMT) No. of bitstreams: 1 CraigAlbertM1971.pdf: 835271 bytes, checksum: b9dc35f18d3c803a016c8efd3b1b33d7 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-01-28T14:52:03Z (GMT) No. of bitstreams: 1 CraigAlbertM1971.pdf: 835271 bytes, checksum: b9dc35f18d3c803a016c8efd3b1b33d7 (MD5)
  • description.provenance : Submitted by Lauren Kaysen (lkscannerosu@gmail.com) on 2014-01-26T23:53:51Z No. of bitstreams: 1 CraigAlbertM1971.pdf: 835271 bytes, checksum: b9dc35f18d3c803a016c8efd3b1b33d7 (MD5)
  • description.provenance : Made available in DSpace on 2014-01-31T17:37:17Z (GMT). No. of bitstreams: 1 CraigAlbertM1971.pdf: 835271 bytes, checksum: b9dc35f18d3c803a016c8efd3b1b33d7 (MD5) Previous issue date: 1970-12-11

Relationships

In Administrative Set:
Last modified: 08/17/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items