Graduate Thesis Or Dissertation
 

Excretion of taurine by normal women

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  • The daily urinary excretion of taurine was studied in six women, 22 to 36 years old. Five subjects collected 24-hour urine specimens for 10 days, and another for 37 days. The subjects were free from any known metabolic disorder. They consumed their normal diet. Urinary taurine was determined by the method of Pentz et al. (1957). Taurine was separated from the other amino acids in urine by treatment with Dowex 50W(H⁺), and reacted with dinitrofluorobenzene to form the dinitrophenol derivative. The derivative was measured photometrically at 360 mμ. In addition to taurine, urinary creatinine was determined by a micro-modification of the method by Folin (Hawk, Oser and Summerson, 1954). The average daily urinary excretion of taurine during the 10 days varied widely among the six subjects, ranging from 60.9 to 196.0 mg per 24 hours. The average excretion of taurine was not related to the subject's age, height, weight or excretion of creatinine. The daily excretion of taurine by each subject varied. Three subjects excreted relatively constant amounts of taurine during the 10-day period; their excretion ranged from 51.0 to 83.3 mg, 66.0 to 105.0 mg and 123.3 to 163.5 mg per 24 hours. The remaining three subjects showed greater variation in taurine execretion; their excretion ranged from 79.5 to 145.5 mg, 84.8 to 187.5 mg and 154.4 to 337.5 mg per 24 hours. This variation in the daily urinary excretion of taurine may have been caused by differences in protein, amino acid and free taurine content of the diet, or stress. A subject who received ACTH to control an allergic reaction to dinitrofluorobenzene excreted increased amounts of taurine on the days the hormone was administered. This subject received seven injections of an ACTH preparation between the 17th and 37th day of urine collection. Taurine excretion was greater on the days ACTH was received than on the day immediately preceding or following each injection. The ingestion of oral contraceptives by two of the subjects did not appear to affect the urinary excretion of taurine. Menstruation appeared to affect the taurine excretion by the two subjects who menstruated during the 10-day period. Results reported by Merrow et al. (1966) indicate that taurine in plasma may be more indicative of vitamin B₆ nutriture than that in urine. In view of this, study on the relationship of taurine in plasma to that excreted in urine by adequately nourished individuals and ones deficient in vitamin B₆ would be of considerable interest. Since the diet consumed by the subjects could affect the urinary excretion of taurine, it is recommended that the subjects be fed a constant diet of known protein, amino acid, taurine and vitamin B₆ content.
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