Graduate Thesis Or Dissertation

 

Lecithin supplementation and free and esterified cholesterol in plasma Public Deposited

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  • The effect of oral lecithin supplementation on plasma lipids was investigated. Thirty-one healthy middle-aged men received 7.2 gm soy lecithin daily for two months. Blood was drawn both before and after supplementation and analyzed for total and esterified cholesterol, total and individual phospholipids, total lipids, triglycerides, and lecithin:cholesterol acyltransferase (LCAT) activity. Information on dietary intake, physical activity, smoking habits and relative weight was also obtained. The proportion of cholesterol ester increased significantly (p < 0.01) with supplementation, as did LCAT activity (p < 0.025). None of the other lipid parameters changed during the experimental period. A positive correlation was found between LCAT activity and the ratio of lysophosphatidyl choline to phosphatidyl choline. Triglycerides were positively correlated with smoking and percent of desirable weight, and negatively correlated with activity level. Higher proportions of cholesterol ester were associated with more vigorous physical activity and with lower relative weights.
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