The investigations of the methods for the reduction of chloropyrimidines Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/gh93h225q

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  • This thesis investigated on the dehalogenation of 2, 4- dichloropyrimidine in various different conditions. These conditions were changed by varying the solvents, the amount of catalysts and the hydrogen chloride acceptors in order to study the effects on the yields. It was found that the ether-aqueous sodium hydroxide medium with palladium on charcoal as the catalysts gave the best yield at the proper time of the reaction only when the ether: water ratio of 5:1. The ethanol was found as the side product during the reduction. The isolation problem of pyrimidine from the reaction mixture was studied and some organic compounds have been used as the "chaser" in the fractional distillation using Podbielniak column. Quinoline, naphthalene, and N, N-dimethylaniline were found to be the effective ones, but o-xylene and mesitylene formed the azeotropic mixture with pyrimidine. The compositions of pyrimidine fractions were identified by the method of gas chromatography analysis.
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-02-28T21:54:53Z (GMT) No. of bitstreams: 1 LadpliVimolvan1970.pdf: 605898 bytes, checksum: ff60c222d102f7a8b538e70fcc6a690d (MD5)
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