Determining the dimensional requirements of a reliable compression sealing method for use in microchannel hemodialysers Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/h702q862j

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  • Almost 600,000 people in the United States were treated for End Stage Renal Disease in 2010. A majority of those people received hemodialysis from central medical facilities. It has been reported a better treatment option for these patients would be realized if the patients had more frequent hemodialysis treatments. A major limiting factor in realizing home hemodialysis treatments is the capital cost of hemodialysis systems and the unit cost of hemodialysers. Microchannel hemodialysers show promise for reducing the size and cost of hemodialysis systems. Cost-effective and reliable sealing techniques for microchannel hemodialysers are required. This paper develops a reliable compression sealing method using sealing bosses in conjunction with an AN69ST hemodialysis membrane for enabling microchannel hemodialysis. The mechanical properties of the AN69ST membranes are determined and used to establish limits on the dimensional tolerances of the polycarbonate laminae and sealing bosses needed to hermetically seal a microchannel hemodialyser. A mathematical relationship is derived for determining the clamping force needed to seal the laminae for a given set of operating parameters and experiments are used to evaluate the model. The method is used to incorporate sealing bosses into a dialysis device and performance is validated using urea mass transfer experiments.
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