Release of patients following the administration of radiopharmaceuticals Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/h702qb37m

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  • As a standard practice, the use of radioactive materials has been widely used when treating many diseases. In recent years advances in biotechnology and labeling techniques have broadened the application of these materials. Candidates selected for radiopharmaceutical therapy may be treated on an outpatient basis or hospitalized following administration to ensure the exposure to their family members, associates at work, medical staff and the general public are ALARA. To maintain compliance with 10 CFR 35.75(a), licensees may release patients immediately following the administration of a radiopharmaceutical if the administered activity is no greater than the amount listed in NUREG 1556, Appendix U, Table U.1 or if it can be shown that members of the general public will not receive a dose greater than 5 mSv during a calendar year. If either of these conditions can't be met licensees are required to hospitalize patients until the second condition can be met. In cases where holding an individual in isolation may be detrimental to the patient it is advantageous, for the sake of the patient's health, to conduct specific patient calculations to release the individual at the earliest opportunity. However, the methods provided by the NRC for conducting patient-specific calculations do not adequately model the patient in terms of geometry and biokinetics. Therefore, a method of demonstrating that a patient is eligible for release without holding the individual in isolation beyond a reasonable time period was developed. The method includes a model for computing patient specific calculations and determining the time requirements for patient specific instructions to be given to the patient following release.
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