Intracellular Measurement of Neurons Using the Sharp Electrode Technique Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/j098zf381

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  • The Brain Research through Advanced Innovative Neurotechnologies (BRAIN) initiative seeks to understand how ensembles of neurons create neural networks. The initiative has spurred the pursuit of developing novel experimental tools for investigating how individual neurons propagate electrical signals (action potentials) to produce ensemble behavior. Classical techniques to measure the internal electrical dynamics of a neuron involve using a glass needle to either pierce through or dock to the membrane of the cell, drawbacks of which include damage to the cell and limits on the temporal resolution and number of simultaneous measurements. Biosensors made from graphene field-effect transistors (GFETs) are promising candidates for externally measuring the electrical activity of individual neurons, which avoids membrane damage. We aim to use the sharp electrode technique to correlate an internal measurement of an action potential with an external GFET measurement to confirm proof-of-concept. This thesis describes the progress made in establishing an experimental system in the Minot lab for making an internal measurement of a Lymnaea stagnalis action potential using the sharp electrode technique.
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