Graduate Thesis Or Dissertation
 

Correlation of habitual diet with plasma risk factors for coronary heart disease

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  • The statistical correlations between habitual diet and plasma risk factors for coronary heart disease CHD were analyzed using multiple regression. Thirty-one male subjects between 30-56 years kept complete dietary records for 7 days. Daily means of nutrient consumption were calculated using a computerized data base. Fourteen independent variables (total kilocalories, protein %, carbohydrate %, fat %, ethanol %, caffeine, P/S ratio, cholesterol, age, weight, height , weight**.75, Body Mass Index, kilocalories/weight**.75) were created. Plasma samples were analyzed and the following simple (total plasma cholesterol (TC), VLDL-C, LDL-C, HDL2-C, HDL3-C, apo A-I, apo A-II, apo B) and derived (VLDL-C+LDL-C, LDL-C/TC, LDL-C/HDL-C, HDL-C, HDL2-C/HDL3-C, HDL-C/TC, apo B/apo A-I, apo B/apo A-II, apo A-Il/apo A-I) dependent variables were created. Dependent variables were individually regressed against the entire set of independent variables. An F-value of 4.00 to enter an independent variable in the model and of 3.99 to remove one were used to achieve significance of p<05. Age appeared in 5 regression models (TC, apo B, apo B/apo A-I, apo B/apo A-II, apo A-Il/apo A-I) and was positively correlated with increased risk for CHD. Total kilocalories appeared in 4 models (LDL-C, apo B, VLDL-C+LDL-C, LDL/TC) and was negatively correlated with risk. Fat % appeared in 4 models (VLDL-C+LDL-C, LDL/TC, LDL-C/HDL-C, HDL-C/TC) and was associated with increased risk. Body Mass Index was entered in 2 models (HDL2-C, HDL-C) and was positively correlated with risk. P/S ratio was negatively correlated with risk in the three models (HDL2, apo A-I, HDL-C) in which it appeared. The independent variable carbohydrate % was negatively associated with risk in 2 models, LDL-C and apo B. Kcal/wt**.75 was also negatively correlated with risk in the VLDL-C, LDL-C/TC and HDL-C/TC models. One independent variable, EtOH %, was positively associated with risk in the apo A-II and apo A-II/apo A-I models. Two dependent variables did not have any independent predictors (HDL3-C, HDL2-C/HDL3-C) entered in their regression models. Six independent variables did not appear in any regression model (protein %, caffeine, cholesterol, weight, height, weight**.75). Independent variables positively correlated with increased risk for CHD were therefore fat %, ethanol %, age, and Body Mass Index. Independent variables correlated with decreased risk for CHD were total kilocalories, carbohydrate %, P/S ratio, and kilocalories/weight**.75.
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