Graduate Thesis Or Dissertation
 

An allometric examination of the relationship between radiosensitivity and mass

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  • The results of a review of six decades of existing literature for 50% lethal dose data across a range of phyla are presented. The collected 50% lethal dose data is limited to adult organisms subjected to acute doses of gamma radiation. The data collected is examined to determine whether useful allometric relationships relating lethal dose and body size can be established. Comparative radiosensitivity is examined where the mechanism of death is the same, and across broader scales where the mechanism of death varies. Various power law fits to graphs of lethal dose vs. mass show a clear increase of radiosensitivity with mass across a number of orders of magnitude, but within an order of magnitude in mass it is difficult to make any useful predictions. The conclusion of this preliminary investigation is that allometric relationships can be useful in providing order of magnitude estimates of radiosensitivity based on mass, but must be used carefully and only as indicators of a general trend.
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