This study investigated three questions: how, what kind of, and why were cross-border partnerships with non-US educational institutions developed at two public four-year US universities; how, what kind of, and why will cross-border partnerships with non-US educational institutions develop and/or change at US universities if nationalistic geo-political trends reflective of xenophobic/nativist sentiments in the US and around the world continue; and how might cross-border partnerships with non-US educational institutions at two public four-year US universities differ from each other in the future if nationalistic geo-political trends reflective of xenophobic/nativist sentiments in the US and around the world continue and what will be the basis for the differences? Semi-structured interviews were conducted with 19 administrators, faculty, and staff from two US public universities who are involved in cross-border partnerships. In this study, both universities were assigned a pseudonym. Data were coded using process coding for the first cycle and pattern coding for the second. Based on a review of the literature of cross-border partnerships, and globalization, cross-border management, and resource dependency theories, an interview protocol was developed. Administration of the protocol and a description of the overall goals of the research were provided to the two US public university Senior International Officers for involvement in the study. Ten participants from Middle System University and nine from West University were selected via purposive sampling through the assistance of the Senior International Officer at each university. Findings demonstrated that participants were concerned how nation-state policies might impact their university’s cross-border partnerships. Participants also suggested that their university’s policies would have to change as a result of changes in US and non-US national policies regarding cross-border collaboration between US and non-US educational institutions. Findings also implied that US universities are highly dependent on the resources within their university and that of the partner university to develop partnerships, that higher educational comprehensive internationalization efforts are being challenged through national policies, and that management of cross-border partnerships require high levels of coordination for them to succeed.