The effect of azetidine-2-carboxylic acid on proline biosynthesis in Escherichia coli

Graduate Thesis Or Dissertation

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Citeable URL: https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/mc87pv322

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Attribute Name	Values
Creator	Smith, Faith Irene
Abstract	The effect of the proline analogue, L-azetidine-2-carboxylic acid, on proline biosynthesis in Escherichia coli has been studied. The analogue inhibits the formation of proline precursor by acting as a false feedback inhibitor, Analysis of kinetic constants in whole-cell preparations indicate that the inhibition is noncompetitive. Comparative inhibitor constants for proline and azetidine-2-carboxylic acid are 5 x 10⁻⁷ M and 4 x 10⁻⁵ M, respectively. The latter constant has been corrected for the amount of inhibitor found in the bacterial cell. The structural specificity of the control mechanism is discussed.
Resource Type	Masters Thesis
Date Available	2014-04-14T21:55:05+00:00
Date Issued	1967-03-10
Degree Level	Master's
Degree Name	Master of Science (M.S.)
Degree Field	Chemistry
Degree Grantor	Oregon State University
Commencement Year	1967
Advisor	Baich, Annette
Academic Affiliation	Chemistry
Non-Academic Affiliation	Oregon State University. Graduate School
Subject	Plant growth inhibiting substances Escherichia coli
Rights Statement	Copyright Not Evaluated
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Digitization Specifications	File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces	http://hdl.handle.net/1957/47303

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