The effect of azetidine-2-carboxylic acid on proline biosynthesis in Escherichia coli Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/mc87pv322

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • The effect of the proline analogue, L-azetidine-2-carboxylic acid, on proline biosynthesis in Escherichia coli has been studied. The analogue inhibits the formation of proline precursor by acting as a false feedback inhibitor, Analysis of kinetic constants in whole-cell preparations indicate that the inhibition is noncompetitive. Comparative inhibitor constants for proline and azetidine-2-carboxylic acid are 5 x 10⁻⁷ M and 4 x 10⁻⁵ M, respectively. The latter constant has been corrected for the amount of inhibitor found in the bacterial cell. The structural specificity of the control mechanism is discussed.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Submitted by Alex McFerrin (amscannerosu@gmail.com) on 2014-04-09T19:48:39Z No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 769817 bytes, checksum: 6dc7be735e1c3cd71e4bb6a90d54fbec (MD5)
  • description.provenance : Submitted by Alex McFerrin (amscannerosu@gmail.com) on 2014-04-11T17:50:22Z No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 793636 bytes, checksum: b5f2dcc886a62feb14610b56846b75e1 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-04-09T19:56:31Z (GMT) No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 769817 bytes, checksum: 6dc7be735e1c3cd71e4bb6a90d54fbec (MD5)
  • description.provenance : Made available in DSpace on 2014-04-14T21:55:05Z (GMT). No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 793636 bytes, checksum: b5f2dcc886a62feb14610b56846b75e1 (MD5) Previous issue date: 1967-03-10
  • description.provenance : Rejected by Patricia Black(patricia.black@oregonstate.edu), reason: replace on 2014-04-11T17:30:08Z (GMT)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2014-04-11T18:00:20Z (GMT) No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 793636 bytes, checksum: b5f2dcc886a62feb14610b56846b75e1 (MD5)
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-04-14T21:55:05Z (GMT) No. of bitstreams: 1 SmithFaithI1967_Redacted.pdf: 793636 bytes, checksum: b5f2dcc886a62feb14610b56846b75e1 (MD5)

Relationships

In Administrative Set:
Last modified: 08/23/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items