Marine natural products possess an abundance of diverse chemical scaffolds with unique biological activities. By targeting unusual or unique microbial environments within varying marine ecologies we can continue to discover novel chemistry with potentially new molecular targets. The research presented here is focused on exploring unusual chemical ecologies and the use of new methods to expedite de- replication for the rapid discovery of new biologically active molecules. Five new micropeptins discovered from a Red Sea cyanobacterium possessed selective inhibition of trypsin-like serine proteases, which are relevant to multiple human health targets. Vitilevuamide, a low nanomolar cancer cytotoxin with high selectivity between cell lines, was rediscovered from a collection of South African tunicates from Algoa Bay, a unique marine environment at a confluence of the Indian and Atlantic Oceans, along with a potential new analog. Molecular networks based on LC-MS2 data were created for the South African tunicate sample collection to aid in identification of putative known compounds or substructure motifs, and to guide prioritization of samples for future work and recollections.
Funding Statement (additional comments about funding)
Financial support is gratefully acknowledged from the OSU College of Pharmacy, NIH R15 GM122016-01 (support of D.A.G.) and Oregon Sea Grant under award number NA10OAR4170064 (project number R/BT-52) from the National Oceanic and Atmospheric Administration’s National Sea Grant College Program, U.S. Department of Commerce, and by appropriations made by the Oregon state legislature.