Gasoline direct injection engines, with downsized boosted technology, present a promising option for enhancing power density and reducing fuel consumption for next-generation engine designs to meet stringent fuel economy and emission standards. However, these developments in the low-speed and high-load operating regime are challenged by the occurrence of a new knocking combustion phenomenon: low-speed pre-ignition. Lubricant oil droplets and their constituents, when diluted with gasoline injection, have been suggested as a key characteristic affecting this phenomenon. We have developed a reduced chemical kinetics model that represents gasoline, lubricant base oil, and oil additive constituents, and validated it against both literature detailed chemical kinetics models and experimental data from jet-stirred reactors and shock tubes. Preliminary application of this reduced chemical kinetics models via direct injection engine simulations at lowspeed, high-load operating conditions has triggered pre-ignition event when a lubricant oil droplet is present in the combustion chamber, indicating a promising outlook for this field of research. This study represents the first step in the development of an effective chemical kinetics model able to be incorporated in a multidimensional computational fluid dynamics framework for engine applications and low-speed pre-ignition investigation.