The synthesis and preliminary pharmacological screening of some benzoyl diamides of ethylenediamine and piperazine Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/ng451m66q

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  • Twelve N, N'-bis(hydroxy- and methoxybenzoyl)ethylenedi-amines and piperazines have been prepared, tested for antifungal activity, and screened for gross pharmacological activity in mice. All twelve compounds showed some activity against Candida albicans, Trichophyton mentagrophytes and Microsporum gypseum but in every case the activity was less than that of salicylanilide used as a control. In the test on mice N, N'-bis(4-hydroxybenzoyl)ethylenedaimine and N, N'-bis(3-methoxybenzoyl)piperazine showed activity (stimulation) after oral administration.
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  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
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  • description.provenance : Submitted by Alex McFerrin (amscannerosu@gmail.com) on 2014-04-24T19:51:27Z No. of bitstreams: 1 LindgrenRichardL1966_Redacted.pdf: 667462 bytes, checksum: 712351af15aa646a361dc3e568cf1cb0 (MD5)
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