Epoxidation of cyclodiene compounds by rat liver microsomes Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/nv9356170

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  • Rat liver microsomes are shown to contain an enzyme system which converts the cyclodiene insecticides, aldrin, heptachlor and isodrin to their corresponding epoxides, dieldrin, heptachlor epoxide, and endrin. The microsomal fraction of 450 milligrams of liver from male rats epoxidates 80 percent of a 20 to 50 microgram aldrin substrate in 20 minutes at 37°C. The pH optimum for these epoxidations is 8.2. The enzymatic activity of the microsomes is retained during two weeks storage at low temperatures. Isodrin, a stereoisomer of aldrin, is less readily oxidized (about 60 percent) under similar conditions. Only 40 percent conversion occurs in the case of heptachlor. Microsomes from female rats are about one-half as active in the conversions as those from males. The role of epoxidation as the first step in the metabolism of these compounds is discussed.
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  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
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  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-06-02T19:22:52Z (GMT) No. of bitstreams: 1 WongDavidT1964.pdf: 324570 bytes, checksum: 85ec0174fbea2c05530bb7dc1e1ad786 (MD5)
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-06-05T16:07:09Z (GMT) No. of bitstreams: 1 WongDavidT1964.pdf: 324570 bytes, checksum: 85ec0174fbea2c05530bb7dc1e1ad786 (MD5)
  • description.provenance : Submitted by Madison Medley (mmscannerosu@gmail.com) on 2014-06-02T19:05:14Z No. of bitstreams: 1 WongDavidT1964.pdf: 324570 bytes, checksum: 85ec0174fbea2c05530bb7dc1e1ad786 (MD5)
  • description.provenance : Made available in DSpace on 2014-06-05T16:07:09Z (GMT). No. of bitstreams: 1 WongDavidT1964.pdf: 324570 bytes, checksum: 85ec0174fbea2c05530bb7dc1e1ad786 (MD5) Previous issue date: 1963-12-16

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