Graduate Thesis Or Dissertation
 

Epoxidation of cyclodiene compounds by rat liver microsomes

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/nv9356170

Descriptions

Attribute NameValues
Creator
Abstract
  • Rat liver microsomes are shown to contain an enzyme system which converts the cyclodiene insecticides, aldrin, heptachlor and isodrin to their corresponding epoxides, dieldrin, heptachlor epoxide, and endrin. The microsomal fraction of 450 milligrams of liver from male rats epoxidates 80 percent of a 20 to 50 microgram aldrin substrate in 20 minutes at 37°C. The pH optimum for these epoxidations is 8.2. The enzymatic activity of the microsomes is retained during two weeks storage at low temperatures. Isodrin, a stereoisomer of aldrin, is less readily oxidized (about 60 percent) under similar conditions. Only 40 percent conversion occurs in the case of heptachlor. Microsomes from female rats are about one-half as active in the conversions as those from males. The role of epoxidation as the first step in the metabolism of these compounds is discussed.
Resource Type
Date Available
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Publisher
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using Capture Perfect 3.0 on a Canon DR-9050C in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces

Relationships

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details WongDavidT1964.pdf 2017-08-16 Public Download