Effect of vitamin B-6 supplementation before strenuous exercise on restoration of plasma urea and ammonia levels Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/q237hv988

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  • The objectives of this study were a) to determine if pyridoxine (PN) supplementation increases the rate at which plasma urea and ammonia return to basal levels, following exercise, b) to determine, by open circuit calorimetry, the utilization of carbohydrates, and c) to further understand vitamin B-6 metabolism during and following strenuous exercise. Six male athletes (age 26 ± 5 years and VO₂ max 66.4 ± 6.9 ml/kg/min) exercised for 1 hour on a cycle ergometer at 72% VO₂ max at two points during a 17 day study. For the first 8 days subjects received daily a placebo solution, while during the next half they received a PN dose (20 mg). Subjects consumed a constant diet the day before, day of, and day after the exercise test. Blood samples were taken the day of the exercise test at fasting (Fl), pre-exercise (PE), during exercise (DE), 1 min post exercise (I'P), 6 hour post exercise (6hP), and the day after the exercise test at fasting (F2). Plasma was analyzed for ammonia, urea, and pyridoxal 5'-phosphate (PLP). ANOVA showed no significant difference between treatments for either plasma ammonia or urea. While there was a significant increase (p<0.001) in plasma ammonia levels over time with the placebo, with supplementation the increase over time was not significant. With PN supplementation, plasma PLP levels were significantly correlated (p<0.05) with plasma ammonia levels at I'P. A slight decrease in plasma urea concentration was observed with the PN treatment at PE, DE, I'P, and 6hP. It was concluded that PN may reduce adverse consequences of plasma ammonia and urea seen with exercise. On the other hand, pyridoxine supplementation may produced a shift in the utilization of substrates of the subjects. Metabolic rate results showed that the contribution of carbohydrates as a energy source increased from 43.5 ± 13.7% with the placebo, to 52.0 ± 6.7% with the PN treatment (not significantly different). This observation lead to the conclusion that PN supplementation decreases glycogen stores compared to the glycogen stores without supplementation. Since the findings from this study suggest slightly more rapid plasma ammonia and urea restoration but decreased glycogen stores, they do not provide evidence for or against an increased need for vitamin B-6 in persons that are involved in strenuous exercises of medium duration.
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-01-26T18:34:20Z (GMT) No. of bitstreams: 1 CAMPUZANOGLORIA1988.pdf: 2027891 bytes, checksum: cffeda95dc2cb7470c12130340686f5a (MD5)
  • description.provenance : Submitted by Erin Clark (ecscannerosu@gmail.com) on 2011-12-28T20:38:49Z No. of bitstreams: 1 CAMPUZANOGLORIA1988.pdf: 2027891 bytes, checksum: cffeda95dc2cb7470c12130340686f5a (MD5)
  • description.provenance : Made available in DSpace on 2012-01-26T18:34:20Z (GMT). No. of bitstreams: 1 CAMPUZANOGLORIA1988.pdf: 2027891 bytes, checksum: cffeda95dc2cb7470c12130340686f5a (MD5) Previous issue date: 1988-03-11
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-01-04T23:10:00Z (GMT) No. of bitstreams: 1 CAMPUZANOGLORIA1988.pdf: 2027891 bytes, checksum: cffeda95dc2cb7470c12130340686f5a (MD5)

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