Graduate Thesis Or Dissertation

 

Analysis of dichotomous response models for low-dose carcinogenic risk estimation Public Deposited

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/q524jr19v

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  • Several dichotomous-response models of carcinogenesis are discussed and their implications for low-dose risk estimation are examined. In addition, a pharmacokinetic model incorporating non-linear kinetics is studied and the results are investigated with respect to multiple-pollutant exposures. None of these models appears to suggest the existence of "thresholds". The analysis of both linear and nonlinear models indicates that if background concentrations are present, then under almost all models discussed, the marginal response associated with the new carcinogen increases more linearly with dose. The results of the study are then examined with respect to dispersal of carcinogenic pollutants as a means of reducing environmental hazards to a given population. It was then concluded that dispersal may not reduce the overall risk if linear or near-linear dose-response relationships are assumed. A conceptual experimental design is also presented to investigate a general relationship between dispersal and total population incidence.
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