Alterations in growth, lipid metabolism and P:O ratios in mice fed Sterculia foetida oil Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/q811kn42w

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Cyclopropenoid fatty acids (CPFA) are natural components of cottonseed oil, a major food oil in the United States. The ability of CPFA to cause abnormal biochemical and physiological effects when fed to laboratory and farm animals has prompted an investigation of their effects on mice. Between 0.05 and 0.55% CPFA were fed as glycerines of Sterculia foetida oil (SFO, containing 55% CPFA) to mice to determine their effect on certain aspects of growth, lipid metabolism and mitochondrial function. One-half percent SFO fed to weanling mice caused a small temporary decrease in growth rate when compared to controls. Many mice fed 1% SFO stopped growing and died by the end of a 9-week feeding trial. Mice fed less than 1% SFO, or 1% SFO for shorter periods of time, showed increased liver-to-body-weight ratios, accumulation of CPFA in adipose tissue and increased ratios of 16:0/16:1, 18:0/18:1 and total saturated to unsaturated fatty acids in liver and depot fat. Erythrocytes from CPFA-fed mice hemolyzed more slowly than erythrocytes from control mice in isotonicnonelectrolytes, implying an effect of CPFA on membrane lipid composition. One-half percent SFO fed for 9 to 31 days inhibited almost completely the incorporation of [¹⁴c] from labeled palmitate or acetate into liver monounsaturated fatty acids. At the same time, 0.5% SFO retarded the incorporation of label from acetate into ¹⁴C₂ and total liver lipid, but stimulated twofold the incorporation into liver sterols. The oxidation of labeled palmitate was also reduced. CPFA caused lipid accumulation in livers. P:0 ratios of liver mitochondria from mice fed 1% SFO for 6 to 15 days were 1.06- 1.45 while control P:0 ratios were 2.30-2.85. The decrease was due to decreased phosphorylation, but increased respiration. The relationship between the observed results and membrane fatty acid composition was discussed.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome, 24-bit Color) using Scamax Scan+ V.1.0.32.10766 on a Scanmax 412CD by InoTec in PDF format. LuraDocument PDF Compressor V.5.8.71.50 used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-01-25T16:53:19Z (GMT) No. of bitstreams: 1 LEHMANMICHAEL1974.pdf: 799343 bytes, checksum: 73f4373ad8ea050e1838d1f558632653 (MD5)
  • description.provenance : Made available in DSpace on 2012-01-25T16:53:19Z (GMT). No. of bitstreams: 1 LEHMANMICHAEL1974.pdf: 799343 bytes, checksum: 73f4373ad8ea050e1838d1f558632653 (MD5) Previous issue date: 1974-06-28
  • description.provenance : Submitted by Erin Clark (ecscannerosu@gmail.com) on 2011-12-20T15:51:46Z No. of bitstreams: 1 LEHMANMICHAEL1974.pdf: 799343 bytes, checksum: 73f4373ad8ea050e1838d1f558632653 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2011-12-20T16:49:45Z (GMT) No. of bitstreams: 1 LEHMANMICHAEL1974.pdf: 799343 bytes, checksum: 73f4373ad8ea050e1838d1f558632653 (MD5)

Relationships

In Administrative Set:
Last modified: 08/08/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items