Suppression of cellular immune responses by Candida albicans Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/qb98mh84p

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  • Experimental infection of mice with Candida albicans leads to significant suppression of cell mediated immune responses. We have characterized the nature of this candida-induced suppression with formalin killed Candida albicans (FKCA) in the yeast and mycelia' phase. Mice (BALB/c or C57B1/6J) treated with FKCA exhibited a reduction in the T-cell mitogen-induced blastogenic response and in the mixed lymphocyte reaction. Further work has shown that the suppression is due to the induction of suppressor cells, and these cells are capable of significantly reducing cellular immune responses when mixed with lymphocytes from untreated mice. The cell responsible for the immunosuppression has been identified as a B-lymphocyte. The function of the suppressor cell is dependent on prostaglandin synthesis during the induction stage. Cell-free supernatants from cultures of suppressor cells are suppressive when added to untreated cells. HPLC analysis of these cell-free supernatants confirmed the presence of prostaglandin, and demonstrated 4 additional components with suppressive activity.
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