Uranium biokinetics in gavaged young adult female rats Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/qb98mj545

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Blood, liver, kidney, femur, and ovaries were assayed from female Wistar rats following oral administration of uranyl nitrate. Three uranium concentrations were studied for six time periods ranging from 4 hours to 240 hours following gavage. Uranium burdens of tissues were determined by neutron activation and delayed fission neutron counting of dried samples. Blood, liver, and ovaries all fell below the minimum level of detection. Femur burdens were converted to skeletal burdens using an empirically determined factor of 19.6. Uptake of uranium by the skeleton and kidneys increased to a peak value followed by a gradual elimination. The maximum skeletal burdens at 30, 3, and 0.3 mg U/kg body weight were 6.6, 3.3, and 0.7 μg U, respectively. The maximum kidney burdens at 30, 3, and 0.3 mg U/kg body weight were 8.5, 6.3, and 0.6 μg U, respectively. The gastrointestinal absorption of uranium was estimated using the sum of the kidney and skeletal burdens. The maximum GI absorption was between 0.3 and 2.1 percent of the dose administered. The biokinetics of female rats were congruous with data from male rats. Evaluating the absorption and kinetics of orally administered uranium is important because substantial concentrations of natural uranium are sometime found in human drinking water.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2013-07-08T21:49:09Z (GMT). No. of bitstreams: 1 KeizerPhilipJ1987.pdf: 368323 bytes, checksum: 6aaaaf3fd517dde4d27c335f670d8ccc (MD5) Previous issue date: 1986-05-28
  • description.provenance : Approved for entry into archive by Deborah Campbell(deborah.campbell@oregonstate.edu) on 2013-07-08T21:49:09Z (GMT) No. of bitstreams: 1 KeizerPhilipJ1987.pdf: 368323 bytes, checksum: 6aaaaf3fd517dde4d27c335f670d8ccc (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2013-06-21T14:46:35Z (GMT) No. of bitstreams: 1 KeizerPhilipJ1987.pdf: 368323 bytes, checksum: 6aaaaf3fd517dde4d27c335f670d8ccc (MD5)
  • description.provenance : Submitted by Katy Davis (kdscannerosu@gmail.com) on 2013-06-20T22:37:56Z No. of bitstreams: 1 KeizerPhilipJ1987.pdf: 368323 bytes, checksum: 6aaaaf3fd517dde4d27c335f670d8ccc (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items