Graduate Thesis Or Dissertation
 

Uranium biokinetics in gavaged young adult female rats

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/qb98mj545

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  • Blood, liver, kidney, femur, and ovaries were assayed from female Wistar rats following oral administration of uranyl nitrate. Three uranium concentrations were studied for six time periods ranging from 4 hours to 240 hours following gavage. Uranium burdens of tissues were determined by neutron activation and delayed fission neutron counting of dried samples. Blood, liver, and ovaries all fell below the minimum level of detection. Femur burdens were converted to skeletal burdens using an empirically determined factor of 19.6. Uptake of uranium by the skeleton and kidneys increased to a peak value followed by a gradual elimination. The maximum skeletal burdens at 30, 3, and 0.3 mg U/kg body weight were 6.6, 3.3, and 0.7 μg U, respectively. The maximum kidney burdens at 30, 3, and 0.3 mg U/kg body weight were 8.5, 6.3, and 0.6 μg U, respectively. The gastrointestinal absorption of uranium was estimated using the sum of the kidney and skeletal burdens. The maximum GI absorption was between 0.3 and 2.1 percent of the dose administered. The biokinetics of female rats were congruous with data from male rats. Evaluating the absorption and kinetics of orally administered uranium is important because substantial concentrations of natural uranium are sometime found in human drinking water.
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