The comparative pharmacodynamics of three organophosphate pesticides on host rabbits and two ectoparasites Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/r494vn62r

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Proban, Famphur and Tiguvon were administered intravenously, subcutaneously, and orally at varying concentrations to 101 female rabbits. The cholinesterase (ChE) activity levels of both plasma and red blood cells were tested, as was tick and mosquito ChE, at various times before and after dosage. The determinations measured the inhibition of ChE due to pesticidal activity. Coxarelations between host blood ChE activity fluctuations and ectoparasite ChE activity were observed. Ectoparasite mortality commenced at 32% ectoparasite ChE activity depression and there was 100% mortality at 68% ChE activity depression, No mortality of ectoparasites was observed to occur between the 24 and 96 hour postdosage period. Mated female ticks that had been exposed to sublethal doses of pesticide laid no eggs. Residue studies indicated that Proban and Famphur were degraded rapidly and excreted in the urine and feces. Tiguvon was more persistent and remained in certain tissues for approximately 28 days. Therapeutic, subcutaneous dosages of all three pesticides eliminated ear mites from rabbits within 24 hours. Reduction in temperature was fatal to mosquitoes that had received sublethal doses of pesticide in their blood meal. Reproductive capabilities of rabbits were not impaired by therapeutic dosages of the pesticides.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi using ScandAll PRO 1.8.1 on a Fi-6770A in PDF format. CVista PdfCompressor 5.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-03-06T18:48:04Z (GMT) No. of bitstreams: 1 SmithHarry1969.pdf: 1793567 bytes, checksum: e1e7b64cb1072ad38cf27b734381c0d8 (MD5)
  • description.provenance : Made available in DSpace on 2014-03-06T18:48:04Z (GMT). No. of bitstreams: 1 SmithHarry1969.pdf: 1793567 bytes, checksum: e1e7b64cb1072ad38cf27b734381c0d8 (MD5) Previous issue date: 1969-04-14
  • description.provenance : Approved for entry into archive by Katy Davis(kdscannerosu@gmail.com) on 2014-03-06T15:53:44Z (GMT) No. of bitstreams: 1 SmithHarry1969.pdf: 1793567 bytes, checksum: e1e7b64cb1072ad38cf27b734381c0d8 (MD5)
  • description.provenance : Submitted by Georgeann Booth (gbscannerosu@gmail.com) on 2014-03-05T23:27:18Z No. of bitstreams: 1 SmithHarry1969.pdf: 1793567 bytes, checksum: e1e7b64cb1072ad38cf27b734381c0d8 (MD5)

Relationships

In Administrative Set:
Last modified: 08/07/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items