Graduate Thesis Or Dissertation

 

Effect of the calpain inhibitor E-64-d on the degradation of α-fodrin in damaged muscle 公开 Deposited

可下载的内容

下载PDF文件
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/rb68xh148

Header

Attribute Name LabelAttribute Values Label
Creator
Abstract
  • We hypothesized that calpain activity is elevated in response to muscle damage. To test this hypothesis, we examined the degradation of α-fodrin into its 150 and 145 kDa fragments following either 20 eccentric or isometric contractions. In addition, experiments were performed in the presence or absence of E-64-d, a calpain inhibitor. Both EDL and SOL muscles displayed significant differences (p<0.003 and p<0.002 respectively) between the raw and normalized 150 and 145 kDa α-fodrin fragments of the DMSO + E-64-d compared to the other bath treatments. Based on our model of exercise-induced muscle damage, we expected to see greater levels of 150 and 145 kDa α-fodrin fragments in those muscles that performed the eccentric protocol. However, there was no evidence that eccentric muscle damage increased the levels of 150 and 145 kDa α-fodrin fragments over the levels observed in the isometric trials. These findings suggest that the magnitude of damage was insufficient to activate calpains.
Resource Type
Date available
Date copyright
Date issued
Degree Level
Degree Name
Degree Field
Degree Grantors
Graduation Year
Contributor Advisor
Contributor Committeemember
Academic Affiliation
Other Affiliation
关键词
Subject
权利声明
Publisher
Language
File Format
File Extent
  • 464645 bytes
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2006-05-23T17:29:31Z (GMT). No. of bitstreams: 1 Jeff Boyd-Thesis.pdf: 464645 bytes, checksum: 2c561e75c8c7b7c30709708272e65fef (MD5)
  • description.provenance : Submitted by Jeffrey Boyd (boydje@onid.orst.edu) on 2006-05-05T18:24:54Z No. of bitstreams: 1 Jeff Boyd-Thesis.pdf: 464645 bytes, checksum: 2c561e75c8c7b7c30709708272e65fef (MD5)
  • description.provenance : Approved for entry into archive by Julie Kurtz(julie.kurtz@oregonstate.edu) on 2006-05-16T19:08:34Z (GMT) No. of bitstreams: 1 Jeff Boyd-Thesis.pdf: 464645 bytes, checksum: 2c561e75c8c7b7c30709708272e65fef (MD5)

关联

Relationships Parent Rows Label

Rows Empty Text

属于 Collection:

单件