The effect of 3,3',4,4',5,5'-hexachlorobiphenyl on production of interleukins 1 and 2 and lymphocyte proliferation in an allogenic response Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/rn301400c

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  • In vivo generation of cytotoxic T cell activity against alloantigen is suppressed by the aromatic hydrocarbon (Ah) receptor binding 3,3',4,4',5,5'- hexachlorobiphenyl isomer (HxCB). Previous studies in this laboratory suggest that HxCB may alter early event(s) in the activation of cytotoxic T lymphocytes (CTL). Production of and response to interleukins 1 and 2 are crucial early events in the generation of effector CTL. In the present study, models were developed to evaluate interleukin 1 (IL 1) production, interleukin 2 (IL 2) production, and the proliferative response to IL 2 in the HxCB treated and control C57B1/6 mice. The model system used throughout was the rejection of the allogeneic P815 mastocytoma. In the case of IL 1 production, the ability of peritoneal exudate cells (PEC) to respond to in vitro stimulation with bacterial lipopolysaccharide (LPS) was also examined. Likewise, IL 2 production in response to Conconavalin A (Con A) was tested. Results suggested there was no significant effect of HxCB on production of either interleukin. The ability of lymphocytes from allosensitized animals to proliferate in response to IL 2 also appeared to be unaffected by HxCB exposure in the experimental model presented here. Thus, while other work in this laboratory suggests that HxCB prevents the normal activation and/or proliferation events that occur in the response to P815 challenge, the production of IL 1 and IL 2 and proliferative response to IL 2 do not appear to be targeted by HxCB.
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