Graduate Thesis Or Dissertation
 

Effects of fractionated radiation doses on survival times of the newt (Taricha granulosa)

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  • This was a study designed to determine the occurrence of recovery from radiation damage in Taricha granulosa. Irradiation with either gamma or x-ray sources in the range of 96-10,000 rads was given. (The mean or median survival times were determined.) Doses were fractionated and the survival times for the same total doses compared. The presence of a significant difference was interpreted as the existence of recovery. Effects upon recovery by the factors of temperature, fraction interval, number of fractions, and dose rate were also tested. Temperature was of primary importance upon the occurrence and/or rate of recovery. If temperature was optimum for recovery the fraction interval based on the radiosensitivity of the cell cycle was the factor of next greatest importance. If the fractionation interval was too short, a merely additive effect of the fractions was observed and no recovery could be detected. The number of fractions seemed to be an effective factor in allowing a significant difference in survival times only if the conditions of temperature and fraction interval were also met. Whether dose-rate has any effect upon recovery could not be determined conclusively from this study.
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