Graduate Thesis Or Dissertation


A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer Public Deposited

Downloadable Content

Download PDF


Attribute NameValues
  • Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic modalities are not adequate: the 5-year mortality rates for stages III-IV ovarian cancer are extremely abysmal, providing only 17% survival rates for patients after treatment. Therefore, there is a dire need for new therapeutic modalities to treat this disease and improve quality of life of patients as they undergo chemotherapy. PARK7/DJ-1 is an oncogenic driver protein in numerous cancers. DJ-1 plays a fundamental role in the growth, survival, and proliferation in cancer. However, targeting of DJ-1 for therapeutic gain in ovarian cancer has not been previously reported. I have designed a nanoparticle-based platform that delivers DJ-1 siRNA to ovarian cancer cells. This system effectively silences DJ-1 expression and suppresses ovarian cancer growth in vitro and in vivo. Further, I have shown that a knockdown of DJ-1 causes an increase in intracellular reactive oxygen species (ROS), and this renders the cancer cells more vulnerable to agents inducing oxidative stress through multiple signaling pathways.
Resource Type
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Committee Member
Academic Affiliation
Rights Statement
Peer Reviewed



This work has no parents.

In Collection: