Graduate Thesis Or Dissertation
 

The anthelmintic activity of SCH 32481 (netobimin[superscript R]) against gastrointestinal nematodes in cattle and sheep and Fasciola hepatica in sheep

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  • The efficacy of a new broad-spectrum anthelmintic, Netobimin[subscript R] (coded SCH 32481-Schering Corporation) was evaluated in two trials conducted during either the spring or fall grazing seasons of 1984 in Western Oregon using 20 cross-bred yearling beef heifers and 30 cross-bred spring lambs, respectively. Percent efficacies were determined in both bovine and ovine hosts harboring naturally acquired gastrointestinal nematode infections and were reported with respect to genera and species of nematode and morphological stage of life cycle when recovered. Fasciolicidal efficacy was concurrently evaluated in the sheep with experimentally induced mature Fasciola hepatica infections. An oral formulation of netobimin was administered in both studies via a modified oral drenching gun to animals randomly divided into groups based on body weight and egg per gram (EPG) counts. Ten heifers received a dose level of 7.5 mg/kg (concentration 150 mg/ml) and 10 remained untreated as controls. Sheep were divided into three groups of ten and received either 7.5 mg/kg or 20 mg/kg of netobimin (concentration 50 mg/ml) or a tap water drench placebo which was given to the control group. All heifers were necropsied two weeks post-treatment and sheep were necropsied either one or two weeks post-treatment. Parasitic gastrointestinal helminths were recovered using standard techniques. Fecal samples were taken throughout the trial and EPG counts monitored. Fecal samples taken on trial termination dates revealed EPG counts (excluding F. hepatica eggs) were reduced in treated heifers by 98% and in treated sheep groups by 62% (7.5 mg/kg) or 100% (20 mg/kg). The overall efficacy against all species of adult nematode found (excluding Trichuris spp.) in the bovine study was 67% (p ≤ 0.05). The overall efficacy in the ovine study against all nematode species including all life stages present was 88% (p ≤ 0.0002) at 7.5 mg/kg and 99% (p ≤ 0.0002) at 20 mg/kg; the respective efficacies against F. hepatica were 62% (p ≤ 0.05) and 91% (p ≤ 0.01). No adverse reactions or signs of toxicosis were observed in either trial.
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